ClinicalEvidence is an UpToDate alternative for teams that need cited answers from registered trials and published studies rather than expert written bedside recommendations. Every sentence links to an NCT number or PMID, and the index covers ClinicalTrials.gov, the EU Clinical Trials Register, WHO ICTRP and PubMed. UpToDate is the better pick for point of care treatment guidance.
UpToDate from Wolters Kluwer is a clinician authored decision support resource. Its topics are written and updated by physician authors and editors, and that editorial layer is exactly what a practicing physician pays for.
Industry and research teams ask different questions. They want to know which trials are running in an indication, what a registered endpoint was, whether results were posted, and what the published evidence says about a comparator. A topic review answers part of that. The rest comes from registries and papers.
ClinicalEvidence is not affiliated with Wolters Kluwer. Pick the tool that matches the deliverable and the sources it must cite.
UpToDate details are summarized from Wolters Kluwer product information. Prices vary by country and license, so confirm current terms with the vendor.
| UpToDate | ClinicalEvidence | |
|---|---|---|
| Who it is for | Clinicians who need expert recommendations at the point of care | Pharma, CRO, medical affairs, HEOR and academic research teams |
| Content | Expert authored and edited clinical topics | AI generated answers from ClinicalTrials.gov, EU CTR, WHO ICTRP and PubMed, index refreshed daily |
| Citations | References listed in each topic | Every sentence cited to an NCT number or PMID, each citation checked before the answer is shown |
| Ongoing trials | Not the focus | Filterable trial table with phase, status, sponsor, enrollment, dates and countries |
| Price | Annual subscription per user, organization licenses by contract | Clinician 49 USD monthly or 24 USD per month billed yearly; Research Team 199 USD monthly or 99 USD per month billed yearly |
| Team seats | Per license | Research Team includes 3 seats, Organization 10, Enterprise up to 50, answers pooled |
| Alerts | Topic update notifications | Alerts on new trials and status changes for a saved question |
| Exports | Not a research export tool | CSV, RIS and BibTeX on every plan; XLSX and DOCX from Research Team |
| Best for | Treatment decisions at the bedside | Landscape, feasibility, medical information and evidence review work |
UpToDate wins on expert synthesis of what to do for a patient. ClinicalEvidence wins on trial level evidence, registry coverage and a source behind each sentence.
Write the condition, the intervention and what you need to know. ClinicalEvidence reads the registries and papers and shows its sources.
Run a clinical trial search across ClinicalTrials.gov, EU CTR, WHO ICTRP and PubMed in one question.
Read the answer. Every sentence carries an NCT number or PMID, and each citation is verified against its source. No verified source, no answer.
Open the trial table and filter by phase, status, sponsor type and country.
Set an alert so new trials and status changes reach the team.
Export the table and references for a response letter, a feasibility deck or a review.
For a wider comparison of paid tools read the OpenEvidence alternative page and our guide to AI tools for medical affairs.
Each sentence links to a trial or paper. Open it and judge whether the passage supports the claim. Verification proves the reference exists and supports the sentence; your team still appraises relevance and quality.
The trial table lists phase, population, interventions, endpoints, results posted, sponsor, status, enrollment, dates and locations. Check the results field before you treat a planned endpoint as an observed finding.
Research Team adds shared workspaces, comments and roles, so a colleague reviews the same evidence before it leaves the team. Organization adds an audit log and invoicing.
If you also treat patients and need expert recommendations at the point of care, keep UpToDate for that and use ClinicalEvidence for the trial and literature questions in between.
ClinicalEvidence carries no advertising. Plans are billed monthly or yearly and answers are pooled across the seats on the plan.
Full limits are on the pricing page.
It depends on the job. For pharma, CRO, medical affairs and research teams that need cited answers from trial registries and publications, ClinicalEvidence is a strong alternative because every sentence links to an NCT number or PMID. For expert written point of care recommendations at the bedside, UpToDate remains the reference and no registry tool replaces its editors.
Wolters Kluwer sells UpToDate as an annual subscription per user and quotes organization licenses by contract, so the figure depends on the buyer and the country. Check the current price on the Wolters Kluwer store. ClinicalEvidence prices are public: Clinician is 49 USD per month or 24 USD per month billed yearly, Research Team is 199 USD per month or 99 USD per month billed yearly.
Not for bedside treatment decisions. UpToDate gives expert synthesized recommendations written by clinicians. ClinicalEvidence answers evidence questions from registered trials and published studies, shows the sources and a trial table, and suits research, medical information, feasibility and HEOR work.
Yes. It indexes ClinicalTrials.gov, the EU Clinical Trials Register and WHO ICTRP daily, so you can see recruiting and planned trials, phase, endpoints and sponsors, and set alerts for new trials and status changes.
Yes. Research Team includes 3 seats and 800 pooled answers, Organization includes 10 seats and 2 000 pooled answers, and Enterprise supports up to 50 seats with SAML SSO.
Bring a real question from your current project, open the citations and the trial table, and see if the registry view answers it.
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