Compare interventions in clinical trials side by side
Choose two to four interventions and see which trials tested each one, in whom, against what, with which endpoints and what they reported. Every cell links to the trial record or paper it comes from.
What an intervention comparison shows
Comparing treatments across trials usually means opening dozens of registry records and abstracts and copying the same fields into a spreadsheet. ClinicalEvidence builds that comparison for you from the index of registered trials and published studies, and keeps the source of every value.
- One column per intervention, two to four in total
- The trials that tested each intervention, with phase and status
- Population and key inclusion criteria as registered
- Comparator arms, including placebo and active controls
- Primary and secondary endpoints with time frames
- Reported results, quoted from posted registry results or publications, with the source cited
- Head to head trials flagged when two of your interventions were tested against each other
- The level of evidence for each cited source
Every value carries an NCT number or PMID. Where a trial has not posted results, the cell says so rather than filling it in.
How comparisons are built and verified
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You name the interventions and, if you want, the condition and filters such as phase, status, date range or results available. ClinicalEvidence retrieves the matching trials and publications for each intervention from the daily refreshed index, writes the comparison only from retrieved passages and runs the same citation verification as every cited AI answer. A value whose source cannot be verified is removed.
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The comparison does not pool results, run a meta-analysis or rank treatments. It shows what each trial reported, side by side, so you can see differences in populations, comparators and endpoints before you draw any conclusion. Indirect comparisons across trials with different designs need your own judgement, and the table makes those design differences visible.
A typical comparison question
A clinical development lead might compare three drug classes for a chronic condition, asking which phase 3 trials tested each one, against which comparators and with which primary endpoints. The result is a single view showing, for example, that one class was tested mostly against placebo with a composite endpoint, while another was tested against an active comparator with a different time frame. The underlying trials open from each cell, and the full list sits in the clinical trial table.
Reading a comparison with care
Trials of different interventions rarely share the same design. A side by side view makes the differences easy to spot, and the comparison highlights them for you.
- Different comparators, such as placebo in one trial and an active control in another
- Different primary endpoints or time frames for what looks like the same outcome
- Different populations, for example prior treatment, disease severity or age range
- Trials that are still recruiting or have not posted results
Use these differences to frame your conclusions, and open the cited records before you quote any value.
Who compares interventions
- HEOR and market access consultants preparing comparisons for payer dossiers. See HEOR evidence review.
- Clinical development teams positioning a new candidate against the current standard of care.
- Medical affairs teams answering questions about how a product compares with alternatives, with the sources attached.
- Physicians and clinical pharmacists checking which options were tested in a population like their own.
Comparisons in every plan
Every plan includes intervention comparisons and evidence summaries. A comparison counts as 5 cited answers, because it reads and verifies many more studies than a single question.
Clinician
- Cited answers per month
- 200
- Comparisons per month at most
- 40
- Seats
- 1
Research Team
- Cited answers per month
- 800 pooled
- Comparisons per month at most
- 160
- Seats
- 3
Organization
- Cited answers per month
- 2 000 pooled
- Comparisons per month at most
- 400
- Seats
- 10
Enterprise
- Cited answers per month
- 6 000 pooled
- Comparisons per month at most
- 1 200
- Seats
- up to 50
The comparisons count comes from your monthly pool, so a month of only comparisons reaches these numbers, and a mix of questions and comparisons shares the same pool. Daily limits apply too: 25 cited answers per day on Clinician, 100 on Research Team, 250 on Organization and 600 on Enterprise. Export comparisons with the formats of your plan, described on the export page. Save 50% with yearly billing, see the pricing page.
Questions about comparing interventions
How many interventions can I compare at once?
Two to four. For a wider question, run several comparisons or use the trial table with an intervention filter.
Does the comparison tell me which treatment is better?
No. It shows what each trial reported, with its population, comparator and endpoints, and cites every value. It does not pool or rank results, so the interpretation stays with you.
Why does a comparison count as 5 cited answers?
A comparison retrieves and verifies evidence for each intervention separately, which takes several times the work of one question.
Compare your next set of interventions with sources attached
Create your account and run your first comparison.